Endometrial Biopsy - EB

The endometrial biopsy is a sampling of the lining of the uterus to evaluate the effect of progesterone on the endometrium as it prepares for implantation. The test is usually performed 10-12 days after ovulation.

On the day of your scheduled biopsy a pregnancy test will be done approximately 1 hour prior to the procedure. If the pregnancy test is negative the biopsy will be performed. If the pregnancy test is positive the biopsy will not be done and further instructions will be given. If you are a recurrent pregnancy loss patient you will be asked to abstain from intercourse during the work-up phase.

Once the tissue is obtained in the office, it will be sent to a laboratory for a pathologist to examine the tissue and determine if the uterus is hormonally prepared for the embryo to implant.

During the procedure you may experience moderate to strong cramping which will subside within a few minutes after the procedure. You may take Tylenol, Motrin or Advil one hour prior to the procedure to decrease any discomfort which may occur. If you experience severe pain, nausea, vomiting, fever or excessive bleeding after the procedure, please contact the office immediately.

To get accurate results from this test, it is important to call the office and leave a message on the nurse’s voicemail with the start of your period. If you are currently using Clomid we need the results of your biopsy before we can prescribe the appropriate dose for the next cycle. We typically receive a report within 5 business days.